Second lung malignancy and Richter syndrome in chronic lymphocytic leukemia: case report and literature review

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Second lung malignancy and Richter syndrome in chronic lymphocytic leukemia: case report and literature review

BACKGROUND Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative disease. Transformation into Richter disease and occurrence of second malignancies involving the lungs are rare complications. The hallmarks of any thoracic involvement are still unknown. CASE PRESENTATION We report a case of a 56-year-old male patient, with history of tobacco smoking, who presented with re...

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Case report and literature review: a rare patient with chronic myeloid leukemia and chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly. However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. In the present report, a 71-yr-old man was diagnosed with Philadelphia (Ph) chromosome positive CML and treated with imatinib mesylate. He went into morphologic, cytogenetic, and molec...

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Richter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease.

r ichter syndrome is a clinical condition in which indolent chronic lymphocytic leukemia evolves into a more aggressive diffuse large B cell lymphoma. Maurice Nethaniel Richter first described this phenomenon in 1928, which was named the “Richter syndrome” in 1964 [1]. Due to the aggressive nature of the disorder, the clinical manifestations, prognosis and treatment differ from CLL1 [2]. Sympto...

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Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article

Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...

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ژورنال

عنوان ژورنال: Multidisciplinary Respiratory Medicine

سال: 2019

ISSN: 2049-6958,1828-695X

DOI: 10.4081/mrm.2017.253